Ryvett
The most comprehensive software platform for design, management and analysis of Cytometry data.
Ryvett is a modular, cloud-based software platform with extensive functionality to support end-to-end cytometry workflows and analysis. Deployed in a single-tenant or multi-tenant configuration, Ryvett is architected and built to be 21 CFR Part 11 compliant with access control, traceability, and audit capabilities. Ryvett’s modules can be deployed independently or together to meet your needs:
- Design Module: Collaborate, design, and plan experiments with automated metadata entry and export acquisition ready experiment files with harmonized annotations across experiments
- Analysis Module: Apply traditional methods and automated algorithms to define cell types, quantify, and apply multiple modes of data analysis with highly interactive visualization to explore single cell data and cross-sample analysis
- Data Warehouse Module: Centralize and harmonize data in an auditable & traceable repository, access data from anywhere, and live connect from excel and other tools
- Operations Module: Manage and report standard assays (e.g. reagent and instrument qualification) with highly automated workflows and interactive dashboards to monitor
Design Module
- Design complex cytometry experiments with complete specification of reagents, conditions, keywords, samples and controls, and instrument control parameters
- Export acquisition ready experiment files to instruments including BD, Cytek, BioRad ZE5, Attune & Novocyte
- Centralized management of reagent listing to maintain consistent name
- Enable lab automation and planning
Analysis Module
- Define cell types, quantify and annotate to precisely meet your use case using a combination of traditional gating, importing from external tools (FlowJo, DIVA XML, Gating ML), rule-based automation, automated enumeration of co-expression, and clustering
- Explore co-expression patterns at the single cell level to drive hypotheses and discovery as well as conduct paired and unpaired differential analysis across samples for biomarker discovery, mechanism of action (MOA), and more
- Share analysis dashboards and export reports
- Translate hypotheses from analysis into database wide mining
Data Warehouse Module
- Compatible with a wide range of instruments, import gating from FlowJo, GatingML, DIVA XML and review in Ryvett
- Specify sample metadata and harmonize annotations including cell types and reagent names across operators, labs, experiments
- Quantify biology in a number of ways including cross-well normalization
- Powerful search engine across the entire warehouse
- Live connect to data from a from various analytics tools including Excel, Tableau, Spotfire and Scripting (e.g. R, python) to support analysis and reporting
Operations Module
- Automate all aspects of standardized and/or validated assays including gating, quantification and reporting with ability to review, edit & lock with audit trail
- Computational gating rules that combine expert knowledge and ML/AI techniques to adopt gates to each dataset
- Built in support for reagent and instrument qualification and monitoring
- Centralize data with live dashboards for monitoring, standardized reporting, and supporting quality systems
- Rapidly configure new assay formats to transition from R&D to standardized assays
